About brigatinib
Anaplastic lymphoma kinase inhibitor
Used for
- Treats ALK-positive advanced non-small-cell lung cancer.
Usual adult dose
Usually 90 mg once daily for 7 days, then 180 mg once daily if tolerated.
Common side effects
- Nausea, diarrhoea, constipation, or vomiting
- Raised blood pressure
- Raised blood sugar
- Cough, breathlessness, or lung inflammation
Important warnings
- Lung inflammation can be serious, especially early in treatment.
- Monitor blood pressure, blood sugar, liver enzymes, and muscle enzymes.
- May cause slow heart rate or visual problems.
- Avoid grapefruit; report new or worsening breathing symptoms promptly.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 4 months afterward.
Breastfeeding
Breastfeeding is not recommended during treatment or for 1 week after the last dose.
Interactions
- Strong CYP3A inhibitors can increase brigatinib levels.
- Strong CYP3A inducers can reduce brigatinib levels.
- Brigatinib may reduce the effectiveness of hormonal contraceptives.
- Avoid St John’s wort.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.