About brigatinib
ALK tyrosine kinase inhibitor
Used for
- Treats ALK-positive advanced non-small-cell lung cancer.
Usual adult dose
Usually 90 mg once daily for 7 days, then 180 mg once daily if tolerated.
Common side effects
- Nausea, diarrhea, constipation, or vomiting
- Fatigue, headache, or muscle pain
- High blood pressure
- Cough or shortness of breath
Important warnings
- Can cause serious lung inflammation, especially early in treatment.
- Monitor blood pressure, heart rate, blood sugar, and liver and pancreatic enzymes.
- Can cause vision problems, severe muscle injury, or slow heartbeat.
- Avoid grapefruit and driving if vision changes or dizziness occur.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for at least 4 months after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment or for 1 week after the last dose.
Interactions
- Strong CYP3A inhibitors can increase brigatinib levels.
- Strong CYP3A inducers can reduce brigatinib levels.
- Brigatinib can reduce hormonal contraceptive effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.