About bosentan
Endothelin receptor antagonist
Used for
- Pulmonary arterial hypertension to improve exercise ability and delay worsening.
Usual adult dose
Usually 62.5 mg twice daily for 4 weeks, then 125 mg twice daily.
Usual dose in children
For children aged 1 year and older, dosing is based on weight, usually twice daily.
Common side effects
- Headache
- Fluid retention or leg swelling
- Flushing
- Abnormal liver tests
Important warnings
- Can cause serious liver injury; regular liver blood tests are required.
- Can cause birth defects; pregnancy must be avoided during treatment.
- May reduce sperm counts and hormonal contraceptive effectiveness.
- Seek urgent care for signs of liver problems, such as yellow skin or dark urine.
Pregnancy
Can cause serious birth defects and must not be used during pregnancy.
Breastfeeding
Unknown whether bosentan passes into breast milk; breastfeeding is not recommended during treatment.
Interactions
- Hormonal contraceptives may be less effective.
- Cyclosporine and glyburide should not be used with bosentan.
- Warfarin levels may change; monitoring may be needed.
- Other medicines can affect bosentan levels; check with a healthcare professional.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.