About bosentan
Endothelin receptor antagonist
Used for
- Treats pulmonary arterial hypertension to improve exercise ability and delay worsening.
Usual adult dose
Usually 62.5 mg twice daily for 4 weeks, then 125 mg twice daily.
Usual dose in children
For pulmonary arterial hypertension, dosing depends on weight and age; specialist-supervised dosing is required.
Common side effects
- Headache, flushing, or nasal congestion
- Swelling or fluid retention
- Anemia
- Abnormal liver tests
Important warnings
- Can cause serious liver injury; regular liver blood tests are required.
- Can cause fetal harm; pregnancy must be avoided during treatment.
- May reduce sperm counts and cause fluid retention.
- Use restricted-access monitoring and prescribing programs in some countries.
Pregnancy
Can cause serious birth defects and must not be used during pregnancy. Effective contraception and pregnancy testing are required.
Breastfeeding
It is not known whether bosentan passes into breast milk; breastfeeding is generally not recommended.
Interactions
- Hormonal contraceptives may be less effective; use additional or alternative contraception.
- Cyclosporine and glyburide are contraindicated.
- May reduce warfarin levels and hormonal contraceptive effectiveness.
- Rifampin and some antifungals can substantially alter bosentan levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.