About bempedoic acid + ezetimbe
Cholesterol-lowering combination
Used for
- Lowers LDL (“bad”) cholesterol in adults with primary hypercholesterolaemia or mixed dyslipidaemia.
- Used with diet and other cholesterol-lowering treatment when needed.
Usual adult dose
One tablet once daily, with or without food.
Common side effects
- Muscle or joint pain
- Raised uric acid or gout
- Diarrhoea or abdominal discomfort
- Raised liver enzymes
Important warnings
- May increase uric acid and cause gout.
- Rarely, tendon injury or rupture can occur.
- Report unexplained muscle pain or weakness, especially with a statin.
- Liver tests may be needed; avoid in severe liver impairment.
Pregnancy
Not recommended during pregnancy; cholesterol-lowering treatment is generally stopped when pregnant.
Breastfeeding
Breastfeeding is not recommended during treatment; discuss an alternative with a healthcare professional.
Interactions
- Statins, especially simvastatin: increased statin exposure and muscle-injury risk.
- Cyclosporine may increase ezetimibe exposure.
- Bile-acid sequestrants can reduce ezetimibe absorption; separate doses.
- Warfarin: monitor clotting (INR) when treatment is started or changed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.