About belumosudil
ROCK2 inhibitor immunosuppressant
Used for
- Treats chronic graft-versus-host disease after prior systemic treatments have not worked well enough.
Usual adult dose
200 mg by mouth once daily with food; some interacting medicines require twice-daily dosing.
Common side effects
- Infections
- Nausea or diarrhea
- High blood pressure
- Abnormal liver tests
Important warnings
- May cause serious infections; report signs such as fever promptly.
- Liver injury can occur; liver tests are monitored during treatment.
- Review medicines for interactions; some reduce or increase belumosudil levels.
- Avoid live vaccines during treatment unless a clinician advises otherwise.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for one week after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment and for one week after the last dose.
Interactions
- Proton pump inhibitors may require a higher belumosudil dose.
- Strong CYP3A inducers can reduce drug levels and may require dose adjustment.
- Belumosudil may affect levels of certain CYP3A or CYP2C9 medicines.
- Antacids and medicines affecting stomach acidity can alter absorption.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.