About baric itinib
Janus kinase (JAK) inhibitor
Used for
- Rheumatoid arthritis
- Atopic dermatitis (eczema)
- Alopecia areata
- Severe COVID-19 in hospitalized adults
Usual adult dose
Usually 2 mg or 4 mg once daily for rheumatoid arthritis; dosing varies by condition and kidney function.
Usual dose in children
Atopic dermatitis: ages 2–17, usually 2 mg once daily; some may increase to 4 mg. Alopecia areata: ages 12 and older, usually 2 mg daily, sometimes increased.
Common side effects
- Upper respiratory infections
- Nausea
- Headache
- Increased cholesterol or liver enzymes
Important warnings
- May increase risk of serious infections, including tuberculosis and shingles.
- Can increase risks of blood clots, major heart events, and certain cancers.
- Blood counts, liver tests, and cholesterol may need monitoring.
- Avoid live vaccines during treatment.
Pregnancy
May cause harm based on animal studies; human pregnancy data are limited. Use is generally avoided during pregnancy.
Breastfeeding
Not recommended during treatment and for four days after the last dose.
Interactions
- Strong OAT3 inhibitors, such as probenecid, can increase baricitinib levels.
- Other potent immunosuppressants or JAK inhibitors may increase infection risk.
- Live vaccines may cause infection and should be avoided.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.