About aztreonam + avibactam
Monobactam antibiotic and beta-lactamase inhibitor
Used for
- Treats serious infections caused by susceptible Gram-negative bacteria, including certain resistant bacteria.
- Used for complicated infections when other antibiotics may not work.
Usual adult dose
Adults: 2 g aztreonam/0.67 g avibactam intravenously every 6 hours, infused over 3 hours; adjust for kidney function.
Common side effects
- Diarrhea
- Nausea or vomiting
- Rash
- Abnormal liver blood tests
Important warnings
- Use only for infections caused or strongly suspected to involve susceptible bacteria.
- Serious allergic reactions can occur, especially with beta-lactam antibiotic allergy.
- Dose adjustment is needed for reduced kidney function.
- Antibiotic use can cause severe, persistent diarrhea due to C. difficile.
Pregnancy
Human pregnancy data are limited. Use when treatment is needed and expected benefits outweigh potential risks.
Breastfeeding
It is unknown whether both medicines pass into breast milk. Consider infant effects and the importance of treatment.
Interactions
- Probenecid may increase aztreonam exposure.
- Other medicines affecting kidney function may increase the risk of adverse effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.