About axitinib
Tyrosine kinase inhibitor
Used for
- Treats advanced kidney cancer in adults, alone or with pembrolizumab or avelumab.
Usual adult dose
Usually 5 mg by mouth twice daily; dose may be adjusted by the cancer specialist.
Common side effects
- Diarrhea, nausea, vomiting, or constipation
- High blood pressure
- Fatigue or weakness
- Hand-foot skin reaction
Important warnings
- Can cause severe high blood pressure, bleeding, blood clots, or heart problems.
- May impair wound healing; treatment is usually paused before planned surgery.
- Can cause liver injury, especially when combined with some cancer medicines.
- Report severe abdominal pain, chest pain, unusual bleeding, or sudden neurological symptoms promptly.
Pregnancy
Can harm an unborn baby. Effective contraception is recommended during treatment and for one week after the final dose.
Breastfeeding
Do not breastfeed during treatment and for two weeks after the final dose.
Interactions
- Strong CYP3A4 inhibitors can increase axitinib levels; examples include ketoconazole and clarithromycin.
- Strong CYP3A4 inducers can reduce axitinib levels; examples include rifampin and carbamazepine.
- Avoid grapefruit and grapefruit juice, which may increase axitinib levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.