About avacopan
C5a receptor antagonist
Used for
- Used with other medicines to treat adults with severe active granulomatosis with polyangiitis or microscopic polyangiitis.
Usual adult dose
30 mg by mouth twice daily with food; reduce to 10 mg twice daily with strong CYP3A4 inhibitors.
Common side effects
- Nausea
- Headache
- Diarrhea
- High blood pressure
Important warnings
- Can cause serious liver injury; liver tests are needed before and during treatment.
- Serious infections may occur; avoid live vaccines during treatment.
- Do not use with severe active liver disease.
- May cause allergic reactions, including swelling or breathing problems.
Pregnancy
Human pregnancy data are limited; animal studies suggest possible fetal harm. Use only if benefits outweigh risks.
Breastfeeding
It is not known whether avacopan passes into breast milk; effects on a nursing infant are unknown.
Interactions
- Strong CYP3A4 inhibitors increase avacopan levels; the dose must be reduced.
- Strong or moderate CYP3A4 inducers can lower avacopan levels; avoid use.
- Avacopan may increase levels of CYP3A4 substrates, including some medicines with narrow safety margins.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.