About atrasentan
Endothelin A receptor antagonist
Used for
- Reduces protein in urine in adults with IgA nephropathy at risk of disease progression.
Usual adult dose
0.75 mg by mouth once daily.
Common side effects
- Fluid retention and swelling
- Anemia
- Liver enzyme increases
- Low blood pressure
Important warnings
- Can cause serious fluid retention or heart failure.
- Monitor liver tests and hemoglobin during treatment.
- Can harm an unborn baby; pregnancy testing and effective contraception are required.
- Avoid use with severe liver impairment.
Pregnancy
Can cause fetal harm. Do not use during pregnancy.
Breastfeeding
Unknown whether it passes into breast milk; breastfeeding is not recommended during treatment.
Interactions
- Strong CYP3A inhibitors can increase atrasentan levels.
- Strong CYP3A inducers can reduce atrasentan levels.
- Other medicines causing fluid retention may increase swelling risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.