About ezetimibe + atorvastatin calcium trihydrate
Cholesterol-lowering combination medicine
Used for
- Lowers LDL (“bad”) cholesterol and other blood fats.
- Used with diet and exercise for high cholesterol or mixed lipid disorders.
- May reduce cardiovascular risk in selected people needing additional LDL lowering.
Usual adult dose
Usually one tablet once daily; dose is individualized to treatment goals and other medicines.
Usual dose in children
For familial hypercholesterolemia, ages 10–17: usually one tablet once daily; specialist supervision is needed.
Common side effects
- Muscle pain or weakness
- Diarrhea or abdominal discomfort
- Headache
- Raised liver enzymes
Important warnings
- Report unexplained muscle pain, tenderness, or weakness; rarely, severe muscle injury occurs.
- Liver injury is possible; liver tests may be needed.
- Avoid during active liver disease or unexplained persistent liver test abnormalities.
- Not recommended during pregnancy; stop if pregnancy occurs.
Pregnancy
Contraindicated during pregnancy because lowering cholesterol is unnecessary and may harm fetal development.
Breastfeeding
Breastfeeding is not recommended while taking this medicine; discuss alternatives with a clinician.
Interactions
- Cyclosporine can increase medicine levels.
- Fibrates, especially gemfibrozil, increase muscle-injury risk.
- Some antibiotics, antifungals, antivirals, and grapefruit can raise atorvastatin levels.
- Warfarin may require closer monitoring.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.