About asfotase alfa
Enzyme replacement therapy
Used for
- Treats hypophosphatasia, a rare inherited disorder affecting bone and teeth mineralisation.
Usual adult dose
Usually 2 mg/kg under the skin three times weekly, or 1 mg/kg six times weekly; maximum 6 mg/kg weekly.
Usual dose in children
Usually 2 mg/kg under the skin three times weekly, or 1 mg/kg six times weekly; maximum 6 mg/kg weekly.
Common side effects
- Injection-site reactions
- Headache
- Fever
- Allergic reactions, rarely severe
Important warnings
- Can cause serious allergic reactions, including anaphylaxis.
- Injection sites may develop skin changes or calcium deposits.
- Eye or kidney calcium deposits can occur; monitoring may be needed.
- Do not inject into areas of active skin changes.
Pregnancy
Human pregnancy information is limited; use only when a clinician considers treatment necessary.
Breastfeeding
It is not known whether asfotase alfa passes into breast milk; discuss risks with a clinician.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.