About artemether + lumefantrine
Artemisinin-based antimalarial combination
Used for
- Treats uncomplicated malaria caused by Plasmodium falciparum.
- Not for preventing malaria or treating severe malaria.
Usual adult dose
Adults weighing at least 35 kg: 4 tablets per dose at 0, 8, 24, 36, 48, and 60 hours.
Usual dose in children
Children: six doses over three days; dose per dose is 1, 2, 3, or 4 tablets by weight bands under 15, 15–24, 25–34, or at least 35 kg.
Common side effects
- Headache
- Dizziness
- Weakness or tiredness
- Nausea, vomiting, or abdominal pain
Important warnings
- Take each dose with food or a milky drink to improve absorption.
- Vomiting soon after a dose may require a replacement dose.
- Not suitable for severe malaria; urgent hospital treatment is needed.
- Use caution with heart rhythm problems or medicines that affect heart rhythm.
Pregnancy
May be used when clinically appropriate; malaria during pregnancy needs prompt treatment. Specialist guidance is important, especially in the first trimester.
Breastfeeding
Small amounts may enter breast milk; limited data are available. Seek clinician guidance, particularly when breastfeeding a young or premature infant.
Interactions
- Avoid strong CYP3A4 inducers such as rifampicin, carbamazepine, phenytoin, and St John’s wort.
- Medicines that prolong the QT interval can increase abnormal heart rhythm risk.
- Some antiretrovirals and antifungals may alter artemether or lumefantrine levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.