About aripiprazole
Long-acting atypical antipsychotic
Used for
- Maintenance treatment of schizophrenia in adults
- Maintenance treatment of bipolar I disorder in adults, in some countries
Usual adult dose
Usually 400 mg by deep intramuscular injection every month; may be reduced to 300 mg for tolerability. Oral aripiprazole is generally continued for 14 days after the first injection.
Common side effects
- Injection-site pain
- Restlessness or difficulty sitting still
- Weight gain
- Sleepiness or insomnia
Important warnings
- Can increase blood sugar, cholesterol, and weight.
- May cause compulsive behaviors, such as gambling or binge eating.
- Older adults with dementia-related psychosis have increased risk of death.
- May cause movement problems, low blood pressure, or impaired temperature regulation.
Pregnancy
Use during pregnancy only when clinically needed; late-pregnancy exposure may cause newborn movement or withdrawal symptoms.
Breastfeeding
Aripiprazole may enter breast milk and can reduce milk supply; discuss risks with a healthcare professional.
Interactions
- Strong CYP2D6 or CYP3A4 inhibitors can raise aripiprazole levels.
- Strong CYP3A4 inducers can lower levels and reduce effectiveness.
- Alcohol and medicines causing sleepiness may worsen drowsiness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.