About argatroban
Direct thrombin inhibitor anticoagulant
Used for
- Prevents or treats blood clots in adults with heparin-induced thrombocytopenia (HIT).
- Anticoagulation during procedures in adults with HIT when needed.
Usual adult dose
For HIT, typically start intravenous infusion at 2 micrograms/kg/min; adjust using aPTT. Lower starting doses may be needed with liver impairment or critical illness.
Common side effects
- Bleeding
- Low blood pressure
- Fever
- Nausea
Important warnings
- Given by intravenous infusion under medical supervision; dosing requires frequent blood tests.
- Bleeding can be serious or life-threatening.
- Use cautiously with liver impairment; the medicine may take longer to clear.
- There is no specific antidote; effects generally lessen after stopping the infusion.
Pregnancy
Human pregnancy data are limited. Use only when clearly needed; anticoagulation risks and benefits require specialist assessment.
Breastfeeding
It is not known whether argatroban enters breast milk. Breastfeeding decisions require specialist assessment.
Interactions
- Other anticoagulants and antiplatelet medicines can increase bleeding risk.
- Medicines affecting blood clotting may alter bleeding risk; clinicians should review all medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.