About aprepitant
Neurokinin-1 receptor antagonist antiemetic
Used for
- Prevents nausea and vomiting from cancer chemotherapy, with other antiemetics.
Usual adult dose
Chemotherapy: 125 mg by mouth on day 1, then 80 mg once daily on days 2 and 3.
Usual dose in children
For children aged 6 months and older, dosing is based on age, weight, and chemotherapy regimen.
Common side effects
- Tiredness
- Hiccups
- Constipation
- Diarrhea
Important warnings
- Use with other prescribed antiemetics for chemotherapy-related nausea.
- May reduce hormonal contraceptive effectiveness during treatment and for 28 days afterward.
- Not for treating nausea that is already occurring.
- Dose adjustments may be needed with certain interacting medicines.
Pregnancy
Limited information; use during pregnancy only when clearly needed.
Breastfeeding
It is unknown whether aprepitant passes into breast milk; discuss risks and benefits with a clinician.
Interactions
- Can reduce effectiveness of hormonal contraceptives.
- Strong CYP3A4 inhibitors can increase aprepitant levels.
- Strong CYP3A4 inducers can reduce aprepitant effectiveness.
- May alter warfarin effects; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.