About apremilast
Phosphodiesterase-4 (PDE4) inhibitor
Used for
- Plaque psoriasis
- Psoriatic arthritis
- Oral ulcers associated with Behçet disease
Usual adult dose
Usually increased gradually over six days, then 30 mg twice daily; dose reduction may be needed with severe kidney impairment.
Common side effects
- Diarrhea, nausea, or vomiting
- Headache
- Upper respiratory infections
- Weight loss
Important warnings
- Mood changes, depression, or suicidal thoughts can occur.
- Severe diarrhea, nausea, or vomiting may cause dehydration.
- Monitor for significant or unexplained weight loss.
- Lower doses are needed with severe kidney impairment.
Pregnancy
Pregnancy data are limited; avoid use during pregnancy unless clearly necessary.
Breastfeeding
Human breastfeeding data are limited; discuss potential risks before use.
Interactions
- Strong enzyme-inducing medicines, such as rifampin, carbamazepine, phenytoin, and St John’s wort, can reduce effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.