About apomorphine hydrochloride
Dopamine agonist
Used for
- Continuous under-the-skin infusion for advanced Parkinson’s disease when other treatments do not adequately control symptoms.
Usual adult dose
Specialist-adjusted continuous infusion, usually starting at 1 mg/hour and titrated to response; maximum commonly 4 mg/hour.
Common side effects
- Nausea and vomiting
- Injection-site nodules or skin reactions
- Sleepiness, dizziness, or fainting
- Hallucinations or confusion
Important warnings
- Initiation and dose adjustment require specialist supervision.
- Can cause low blood pressure, sleep attacks, or involuntary movements.
- Avoid intravenous use; injection sites need regular care.
- Do not combine with ondansetron or other 5-HT3 antiemetics.
Pregnancy
Use during pregnancy only when clearly needed; human safety information is limited.
Breastfeeding
Breastfeeding is generally not recommended during treatment because effects on the infant are unknown.
Interactions
- Dopamine-blocking medicines, including many antipsychotics, may reduce its effect.
- Ondansetron and related antiemetics can cause severe low blood pressure.
- Sedatives and blood-pressure-lowering medicines can worsen sleepiness or fainting.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.