About antithrombin iii
Plasma-derived anticoagulant protein
Used for
- Treats inherited antithrombin deficiency when clotting risk is high.
- Prevents or treats blood clots in people with antithrombin deficiency.
- Treats acquired antithrombin deficiency in selected clinical situations.
Usual adult dose
Individualized by body weight, antithrombin blood levels, and clinical situation; given intravenously.
Usual dose in children
Individualized by weight and antithrombin levels; given intravenously under specialist care.
Common side effects
- Bleeding
- Allergic reactions, including rare severe reactions
- Fever or chills
- Injection-site reactions
Important warnings
- Requires monitoring of antithrombin levels and clotting or bleeding.
- May increase bleeding risk, especially with heparin or other anticoagulants.
- Use cautiously with a history of allergy to plasma-derived products.
- Plasma-derived products carry a very low residual risk of transmitting infection.
Pregnancy
May be used when clinically necessary; pregnancy-specific risks and benefits require specialist assessment.
Breastfeeding
Safety information is limited; use should be assessed by a healthcare professional.
Interactions
- Heparin and low-molecular-weight heparins: antithrombin can enhance their anticoagulant effects.
- Other anticoagulants: may increase bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.