About andexanet alfa
Factor Xa inhibitor reversal agent
Used for
- Reverses apixaban or rivaroxaban during life-threatening or uncontrolled bleeding.
Usual adult dose
Given by intravenous infusion; low- or high-dose regimens depend on the anticoagulant, dose, and timing.
Common side effects
- Blood clots
- Infusion-related reactions
- Nausea
- Confusion
Important warnings
- Can cause serious blood clots, including stroke and heart attack.
- Restarting anticoagulation may be needed when medically appropriate.
- Use only in monitored settings for severe or uncontrolled bleeding.
- May interfere with some laboratory tests of blood clotting.
Pregnancy
Human pregnancy data are limited; use only when potential benefit justifies possible risk.
Breastfeeding
It is unknown whether andexanet alfa passes into breast milk.
Interactions
- Heparin: may cause heparin resistance; avoid using heparin after treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.