About anakinra
Interleukin-1 receptor antagonist
Used for
- Rheumatoid arthritis in adults
- Neonatal-onset multisystem inflammatory disease (NOMID)
- Deficiency of interleukin-1 receptor antagonist (DIRA)
Usual adult dose
Rheumatoid arthritis: 100 mg injected under the skin once daily. DIRA: individualized specialist dosing.
Usual dose in children
NOMID: starting dose 1–2 mg/kg injected under the skin daily; specialist adjusts. DIRA: individualized specialist dosing.
Common side effects
- Injection-site reactions
- Headache
- Nausea
- Infections, including serious infections
Important warnings
- Serious infections may occur; treatment is generally avoided during active infection.
- Blood cell counts may fall; monitoring is recommended.
- Avoid live vaccines during treatment.
- Use caution with kidney impairment; dose intervals may need adjustment.
Pregnancy
Human pregnancy information is limited; use only when a clinician determines it is necessary.
Breastfeeding
Information is limited; discuss potential benefits and risks with a clinician.
Interactions
- Other medicines that suppress the immune system may increase infection risk.
- TNF-blocking medicines, such as etanercept, may increase infection risk when combined.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.