About amyl nitrite + sodium nitrite + sodium thiosulfate
Cyanide antidote combination
Used for
- Emergency treatment of cyanide poisoning.
Usual adult dose
Protocol-dependent: amyl nitrite inhalation, followed by sodium nitrite 300 mg intravenously, then sodium thiosulfate 12.5 g intravenously.
Usual dose in children
Protocol-dependent and based on body weight; pediatric doses are lower. Used for cyanide poisoning.
Common side effects
- Low blood pressure, dizziness, headache, or fainting
- Methemoglobinemia and impaired oxygen delivery
- Nausea or vomiting
Important warnings
- Emergency use only; treatment must be given by trained clinicians.
- Nitrites can cause severe low blood pressure and methemoglobinemia.
- Use caution when carbon monoxide poisoning or smoke inhalation is also suspected.
- Dosing and repeat treatment depend on the poisoning protocol and patient response.
Pregnancy
Use only for life-threatening cyanide poisoning; untreated poisoning threatens both pregnant patient and fetus.
Breastfeeding
Breastfeeding considerations are not well established; emergency treatment should not be delayed for cyanide poisoning.
Interactions
- Other blood-pressure-lowering medicines may worsen hypotension.
- Medicines or chemicals that cause methemoglobinemia may increase risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.