About amoxicillin + clavulanate
Penicillin antibiotic plus beta-lactamase inhibitor
Used for
- Bacterial sinus, ear, throat, and chest infections
- Urinary tract infections
- Skin and soft-tissue infections
- Dental infections
Usual adult dose
Commonly 500/125 mg every 8 hours or 875/125 mg every 12 hours, depending on infection and kidney function.
Usual dose in children
For children under 40 kg, dosing is based on the amoxicillin component and varies by infection; use a suitable pediatric formulation.
Common side effects
- Diarrhea, nausea, or vomiting
- Rash or itching
- Thrush
- Rarely, liver inflammation or jaundice
Important warnings
- Not effective against viral infections.
- Avoid with serious penicillin allergy; seek urgent care for breathing difficulty or facial swelling.
- May cause severe diarrhea or liver problems; report persistent symptoms or jaundice.
- Dose may need adjustment in kidney disease.
Pregnancy
Generally used when needed; a clinician should assess the infection and treatment.
Breastfeeding
Usually compatible; monitor the infant for diarrhea, rash, or thrush.
Interactions
- Warfarin and similar anticoagulants: may alter clotting tests.
- Allopurinol: increased likelihood of skin rash.
- Probenecid: can increase amoxicillin levels.
- Methotrexate: may increase methotrexate exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.