About amikacin sulphate
Aminoglycoside antibiotic
Used for
- Serious infections caused by susceptible bacteria, including certain hospital-acquired infections
- Infections due to some bacteria resistant to other antibiotics
Usual adult dose
Usually 15 mg/kg daily by IV or IM, given once daily or in divided doses; dosing is adjusted for kidney function and blood levels.
Usual dose in children
Usually 15–20 mg/kg daily by IV or IM, once daily or in divided doses; dosing is adjusted for age, kidney function, and blood levels.
Common side effects
- Kidney damage
- Hearing or balance problems, sometimes permanent
- Nausea
- Injection-site pain
Important warnings
- Kidney function and blood levels require monitoring during treatment.
- Report hearing loss, ringing in the ears, dizziness, or reduced urination promptly.
- Risk of toxicity increases with kidney disease, dehydration, or prolonged treatment.
- Use only for bacterial infections; resistance can develop.
Pregnancy
May harm the developing baby's hearing; use during pregnancy only when clearly needed.
Breastfeeding
Small amounts may enter breast milk; infant absorption is expected to be low. Monitor for diarrhea or thrush.
Interactions
- Other kidney- or ear-damaging medicines, including vancomycin and some diuretics, can increase toxicity.
- Neuromuscular blockers and some anesthetics may increase muscle weakness or breathing problems.
- Other aminoglycoside antibiotics can increase kidney and hearing risks.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.