About alteplase + vial
Recombinant tissue plasminogen activator
Used for
- Dissolving clots in certain heart attacks, strokes, and blocked catheters
- Treating massive pulmonary embolism with unstable circulation
Usual adult dose
Dose depends on the condition and body weight; given by intravenous infusion. Stroke: 0.9 mg/kg, maximum 90 mg. Heart attack and pulmonary embolism use different regimens.
Common side effects
- Bleeding, including serious internal or brain bleeding
- Nausea or vomiting
- Low blood pressure
- Allergic reactions
Important warnings
- Use only in hospital under specialist supervision.
- Bleeding risk is higher after recent surgery, injury, or bleeding disorders.
- Not suitable for some people with active bleeding or previous brain haemorrhage.
- Stroke treatment requires brain imaging and strict timing criteria.
Pregnancy
Use only when the expected benefit outweighs potential risks; pregnancy-specific evidence is limited.
Breastfeeding
Information is limited; specialist advice is needed for urgent treatment.
Interactions
- Anticoagulants and antiplatelet medicines increase bleeding risk.
- Other medicines that affect clotting may increase bleeding risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.