About alogliptin + pioglitazone
DPP-4 inhibitor and thiazolidinedione combination
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
One tablet once daily, with or without food; dose may need adjustment for kidney problems.
Common side effects
- Swelling, weight gain, or fluid retention
- Low blood sugar, especially with insulin or sulfonylureas
- Upper respiratory symptoms or headache
- Bone fractures; possible heart failure
Important warnings
- Not for type 1 diabetes or diabetic ketoacidosis.
- Pioglitazone can cause or worsen heart failure; avoid in severe heart failure.
- Seek urgent assessment for severe, persistent abdominal pain, which may indicate pancreatitis.
- May increase fracture risk; bladder cancer risk is uncertain.
Pregnancy
Generally not recommended; insulin is usually preferred for diabetes during pregnancy.
Breastfeeding
Unknown whether the medicines pass into breast milk; use requires clinical assessment.
Interactions
- Insulin or sulfonylureas increase low blood sugar risk.
- Strong CYP2C8 inhibitors, such as gemfibrozil, can increase pioglitazone exposure.
- Strong CYP2C8 inducers, such as rifampicin, can reduce pioglitazone exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.