About alogliptin benzoate + metformin hcl
DPP-4 inhibitor and biguanide antidiabetic
Used for
- Improves blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
Usual adult dose
Usually one tablet containing alogliptin 12.5 mg and metformin 500 mg twice daily with meals; dose depends on kidney function and prior treatment.
Common side effects
- Diarrhea, nausea, or stomach discomfort
- Headache
- Upper respiratory infection
- Low blood sugar, especially with insulin or sulfonylureas
Important warnings
- Rare but serious lactic acidosis; risk increases with kidney impairment, severe illness, or heavy alcohol use.
- Avoid in severe kidney impairment; kidney function should be checked before and during treatment.
- Stop and seek urgent care for severe, persistent abdominal pain, which may indicate pancreatitis.
- Metformin may need temporary interruption around certain contrast imaging procedures or surgery.
Pregnancy
Use in pregnancy requires clinician review; insulin is generally preferred for diabetes control during pregnancy.
Breastfeeding
Metformin passes into breast milk; alogliptin breastfeeding data are limited. Discuss use with a healthcare professional.
Interactions
- Insulin or sulfonylureas can increase low-blood-sugar risk.
- Alcohol increases the risk of metformin-associated lactic acidosis.
- Iodinated contrast can affect kidney function and may require temporary interruption.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.