About allopurino l
Xanthine oxidase inhibitor
Used for
- Prevention of gout attacks and uric acid buildup
- Prevention of uric acid kidney stones
- Prevention of high uric acid during some cancer treatments
Usual adult dose
Gout: usually 100 mg daily, increased gradually as needed. Cancer treatment: commonly 300–800 mg daily, guided by clinical monitoring.
Usual dose in children
For cancer-related high uric acid: typically 10 mg/kg daily in divided doses; specialist dosing is required.
Common side effects
- Rash
- Nausea or diarrhea
- Liver test changes
- Sleepiness or dizziness
Important warnings
- A severe rash or allergic reaction can occur; stop treatment and seek urgent care if these develop.
- A gout flare may occur when treatment starts; prescribed preventive treatment may reduce this risk.
- Dose may need adjustment in kidney or liver disease.
- Drink adequate fluids unless medically restricted.
Pregnancy
Use when clearly needed; pregnancy data are limited, so treatment should be reviewed by a clinician.
Breastfeeding
Allopurinol and its active metabolite enter breast milk; use requires clinician review, especially for newborns.
Interactions
- Azathioprine or mercaptopurine: allopurinol can greatly increase their effects and toxicity.
- Warfarin: may increase anticoagulant effects; monitoring may be needed.
- Theophylline: blood levels may rise.
- Some antibiotics, especially amoxicillin or ampicillin, may increase rash risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.