About alitretinoin
Oral retinoid
Used for
- Severe chronic hand eczema in adults that has not responded to strong topical corticosteroids.
Usual adult dose
Usually 10 or 30 mg once daily with food for 12–24 weeks; dose depends on response and tolerability.
Common side effects
- Headache
- Dry, red, or irritated skin and lips
- Raised blood fats
- Changes in liver tests
Important warnings
- Causes severe birth defects; pregnancy must be avoided during treatment and for one month afterward.
- Pregnancy prevention and testing are required for people who can become pregnant.
- Do not donate blood during treatment or for one month afterward.
- Monitor blood fats and liver function; avoid excess vitamin A and sun exposure.
Pregnancy
Must not be used during pregnancy; it can cause severe birth defects.
Breastfeeding
Avoid during breastfeeding; safety is not established and harm is possible.
Interactions
- Vitamin A supplements and other retinoids may increase toxicity.
- Tetracycline antibiotics may raise pressure around the brain.
- Some medicines, including strong CYP3A4 inhibitors, can alter alitretinoin levels.
- Avoid St John’s wort, which may reduce effectiveness.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.