About aliskiren hemifumarate
Direct renin inhibitor
Used for
- Treats high blood pressure.
Usual adult dose
Usually 150 mg once daily; may increase to 300 mg once daily.
Usual dose in children
For ages 6–17: usually 2 mg/kg once daily, up to 150 mg; may increase to 4 mg/kg, up to 300 mg.
Common side effects
- Diarrhea
- Dizziness
- Cough
- High potassium levels
Important warnings
- Can cause dangerously low blood pressure or kidney problems.
- Avoid combining with ACE inhibitors or ARBs in people with diabetes.
- Avoid during pregnancy; stop if pregnancy occurs.
- Not recommended for children under 6 or those with severe kidney impairment.
Pregnancy
Can harm or cause death to the developing baby, especially later in pregnancy. Avoid; discontinue if pregnancy occurs.
Breastfeeding
Not recommended; there is limited information about safety during breastfeeding.
Interactions
- ACE inhibitors or ARBs: increased risk of kidney problems, low blood pressure, and high potassium.
- Cyclosporine or itraconazole: can greatly increase aliskiren levels.
- Potassium supplements or potassium-sparing diuretics: may increase blood potassium.
- High-fat meals reduce absorption; take consistently with or without food.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.