About agomelatine
Melatonin receptor agonist antidepressant
Used for
- Treatment of major depressive episodes in adults
Usual adult dose
25 mg once daily at bedtime; may increase to 50 mg after two weeks if needed.
Common side effects
- Headache
- Dizziness
- Nausea
- Raised liver enzymes
Important warnings
- Liver injury can occur; liver-function monitoring is required.
- Avoid in liver disease or with medicines that strongly inhibit CYP1A2.
- Stop treatment if symptoms suggest liver injury, such as dark urine or yellow skin.
- May cause mania or suicidal thoughts, particularly early in treatment.
Pregnancy
Use during pregnancy is generally not recommended because evidence is limited.
Breastfeeding
Breastfeeding is generally not recommended during treatment; discuss alternatives with a clinician.
Interactions
- Fluvoxamine and ciprofloxacin can greatly increase agomelatine levels.
- Avoid alcohol because it may increase liver-related risk.
- Smoking can reduce agomelatine levels and treatment effect.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.