About agomelati ne
Melatonin receptor agonist and serotonin antagonist
Used for
- Treatment of major depressive episodes in adults.
Usual adult dose
25 mg once daily at bedtime; may increase to 50 mg after two weeks if needed.
Common side effects
- Headache
- Dizziness or sleepiness
- Nausea
- Raised liver enzymes
Important warnings
- Liver injury can occur; liver-function tests are needed before and during treatment.
- Avoid in people with liver disease or significant alcohol use.
- Seek urgent help for yellow skin, dark urine, or unexplained severe fatigue.
- Not recommended for people aged 75 years or older.
Pregnancy
Use during pregnancy is generally avoided because information is limited; a clinician should assess need.
Breastfeeding
Breastfeeding is generally not recommended during treatment because safety information is limited.
Interactions
- Fluvoxamine and ciprofloxacin can greatly increase agomelatine levels; avoid combination.
- Alcohol may increase liver risk and should be avoided.
- Smoking can lower agomelatine levels and reduce its effect.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.