About acyclovir
Antiviral nucleoside analogue
Used for
- Severe herpes simplex infections, including encephalitis
- Severe chickenpox or shingles, especially in people with weakened immunity
- Herpes infections in newborns
Usual adult dose
Usually 5–10 mg/kg intravenously every 8 hours, adjusted for infection and kidney function.
Usual dose in children
Usually 10–20 mg/kg intravenously every 8 hours; newborn dosing depends on age and infection.
Common side effects
- Nausea or vomiting
- Inflamed vein at infusion site
- Kidney injury, especially with dehydration or rapid infusion
- Confusion, tremors, or seizures, particularly with kidney impairment
Important warnings
- Requires slow infusion and adequate hydration; kidney function and dose need monitoring.
- Dose adjustment is needed for kidney impairment.
- Rarely causes severe allergic reactions or blood disorders.
- For intravenous use by healthcare professionals only.
Pregnancy
May be used when clinically needed; available evidence has not shown increased birth-defect risk.
Breastfeeding
Acyclovir enters breast milk in small amounts; treatment is generally considered compatible with breastfeeding.
Interactions
- Probenecid can increase acyclovir levels.
- Other medicines that affect the kidneys may increase kidney-injury risk.
- Theophylline levels may rise; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.