About acalabrutinib
Bruton tyrosine kinase inhibitor
Used for
- Treats chronic lymphocytic leukemia and small lymphocytic lymphoma.
- Treats mantle cell lymphoma in certain adults.
Usual adult dose
Usually 100 mg by mouth every 12 hours for approved uses; follow the prescribed regimen.
Common side effects
- Headache, diarrhea, muscle or joint pain.
- Bruising, fatigue, nausea, or upper respiratory infections.
- Low blood-cell counts and increased infections.
- Bleeding, heart rhythm changes, or high blood pressure.
Important warnings
- Can cause serious bleeding; risk may increase with blood thinners.
- May cause serious infections and low blood-cell counts.
- Can cause irregular heartbeat or high blood pressure.
- Avoid live vaccines; capsules must be swallowed whole.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for one week after the last dose.
Breastfeeding
Do not breastfeed during treatment and for two weeks after the last dose.
Interactions
- Acid-reducing medicines can lower absorption; instructions depend on the medicine.
- Strong CYP3A inhibitors can raise levels; strong CYP3A inducers can lower them.
- Avoid grapefruit and Seville oranges.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.