About abemacicli b
Cyclin-dependent kinase 4/6 inhibitor
Used for
- Treats certain hormone receptor-positive, HER2-negative advanced breast cancers.
- Used with hormone therapy or, in some cases, alone.
Usual adult dose
Usually 150 mg by mouth twice daily with hormone therapy; 200 mg twice daily alone. Doses may be reduced.
Common side effects
- Diarrhea
- Low white blood cell counts
- Nausea and vomiting
- Fatigue
Important warnings
- Can cause severe diarrhea, dehydration, or infection from low blood counts.
- Rarely causes blood clots, lung inflammation, or liver injury.
- May cause fetal harm; effective contraception is required during treatment.
- Avoid grapefruit and strong CYP3A inhibitors or inducers.
Pregnancy
May harm an unborn baby. Pregnancy is generally avoided during treatment and for at least three weeks afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least three weeks after the last dose.
Interactions
- Strong CYP3A inhibitors can increase drug levels; dose adjustment may be needed.
- Strong CYP3A inducers can reduce effectiveness.
- Grapefruit may increase drug levels.
- May increase levels of some CYP3A-substrate medicines.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.