About aandexanet alfa
Recombinant factor Xa inhibitor reversal agent
Used for
- Reverses anticoagulant effects of apixaban or rivaroxaban during life-threatening or uncontrolled bleeding.
Usual adult dose
Given by intravenous bolus followed by infusion. Dose depends on the anticoagulant, last dose, and time since dosing.
Common side effects
- Blood clots, including stroke or heart attack
- Infusion reactions
- Urinary tract infections
- Confusion
Important warnings
- Use is limited to life-threatening or uncontrolled bleeding.
- Reversal can increase the risk of blood clots.
- Restarting anticoagulation may be needed when medically appropriate.
- May cause inaccurate results with some blood-clotting tests.
Pregnancy
Safety in pregnancy is not established; use only when clearly needed.
Breastfeeding
It is not known whether this medicine passes into breast milk.
Interactions
- Heparin may not work properly after treatment; avoid using it immediately afterward.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.